$GLOBALS['TCA']['tt_content']['types'][$myCType]['columnsOverrides']['imagecols']['config']['items'] = [[2,2],[3,3]];
But above not working it just replace fist two items with my list but other items are still visible how can i override items array for my custom ctype?
It seems, \TYPO3\CMS\Core\Utility\ArrayUtility::mergeRecursiveWithOverrule(), which is used to handle the columnsOverrides, does allow unsetting a key (or array), but not replacing a substructure. Maybe it's possible to find a combination of unsetting and afterwards merging with new values.