Integrating SignalR with .net framework 4.5

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Can I integrate ASP.NET SignalR (not .NET CORE SignalR) with .net framework 4.5 and WCF REST and Windows server 2012 R2.

Can I use any of the versions? SignalR or SignalR-2?

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Frank M On

I run that same stack with no problem. Check the supported platforms which are documented.