Get otvdm (aka winevdm) to run 16-bits applications automatically

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I am working on the a project that requires me to run a Makefile which calls on several 16-bit .exe scattered in my F drive. I have looked into using otvdm (aka winevdm) to run the 16-bit applications though I am looking for a way to get them run to automatically when a called on. The current setup of otvdm is having manual selection from the user. What I want is when a 16-bit application is called, it would use otvdm to run the application without me getting involved. Looking for ideas to do this or work around it?

My 64-bit Windows 10 OS rejects any 16-bit applications from running.

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From the readme at https://github.com/otya128/winevdm .

How to install

Download or compile Run "install" shortcut or right-click on install.inf and select "Install" You can execute Win16 binaries directly!>

If the registry is initialized by Windows Update, perform the above procedure again.

You can uninstall it by running uninstall.reg.

You probably want to use the (no console) link.