It is working on the web but not on the desktop. I have read all the available threads already but I am still not able to figure out the reason
Please guide, any help would be appreciated
My Manifest is compatible with outlook 2013 or later, what can be the reason?

Do you get any errors?
The Troubleshoot user errors with Office Add-ins page describes the information to help resolve common issues that your users or you encounter with an Office Add-in.
You can also use Fiddler to identify and debug issues with your add-ins.