Suitable technology for scalable cloud app with API for approx 100K requests per minute

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I'm C# dev with focus on mobile apps and desktop, I've never done anything which includes cloud, cloud apps, web or cloud API (other than WCF). What is latest (LTS) technology for simple API with its own database (one or two tables at most) ? Majority of the requests wouldn't need write access to DB. Could you hold data in memory like cache and synchro it once in a while ? What is the best approach to achieve this ? Scalability is a must as it should be able to serve approx 100K requests per minute in peek. Preferably it should be something from Azure and .NET, but its so huge that I don't know whats best combination for it.

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